Intradermal needle-free powdered drug injection by a helium-powered device

Annu Int Conf IEEE Eng Med Biol Soc. 2012:2012:2068-71. doi: 10.1109/EMBC.2012.6346366.

Abstract

We present a new method for needle-free powdered drug injection via a bench-top gas-powered device. This injector provides an alternative method of vaccine delivery to address the cold chain problem--the cost and risk of transporting temperature sensitive vaccines to developing countries. The device houses interchangeable nozzle inserts to vary orifice geometries and is capable of delivering polymer beads (1-5 µm diameter) into the dermal layer of porcine tissue. Results for injection shape and injection depth versus nozzle orifice diameter demonstrate the device's controllability.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Electric Power Supplies*
  • Equipment Design
  • Equipment Failure Analysis
  • Helium*
  • Injections, Intradermal / instrumentation*
  • Injections, Jet / instrumentation*
  • Needles
  • Powders / administration & dosage
  • Swine
  • Vaccination / instrumentation*
  • Vaccines / administration & dosage*

Substances

  • Powders
  • Vaccines
  • Helium