1,3,5-Trisubstituted benzenes as fluorescent photoaffinity probes for human carbonic anhydrase II capture

Partha Sarathi Addy; Baisakhee Saha; N D Pradeep Singh; Amit K Das; Jacob T Bush; Clarisse Lejeune; Christopher J Schofield; Amit Basak

doi:10.1039/c3cc38251f

1,3,5-Trisubstituted benzenes as fluorescent photoaffinity probes for human carbonic anhydrase II capture

Chem Commun (Camb). 2013 Mar 7;49(19):1930-2. doi: 10.1039/c3cc38251f. Epub 2013 Jan 30.

Authors

Partha Sarathi Addy¹, Baisakhee Saha, N D Pradeep Singh, Amit K Das, Jacob T Bush, Clarisse Lejeune, Christopher J Schofield, Amit Basak

Affiliation

¹ Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.

PMID: 23364467
DOI: 10.1039/c3cc38251f

Abstract

The synthesis of small molecule based 1,3,5-trisubstituted benzenes for photo-mediated capture of human carbonic anhydrase II with visualisation by fluorescence is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzene / chemistry*
Carbonic Anhydrase II / chemistry*
Enzymes, Immobilized / chemistry*
Fluorescent Dyes / chemistry*
Humans
Photoaffinity Labels / chemistry*

Substances

Enzymes, Immobilized
Fluorescent Dyes
Photoaffinity Labels
Carbonic Anhydrase II
Benzene

Grants and funding

Wellcome Trust/United Kingdom