Abstract
A facile, versatile, and one-pot sonochemical synthesis of polydopamine (PDA)-nanocapsules from dopamine is reported. The nanocapsules (227 ± 25 nm) can encapsulate hydrophobic substances while retaining the reactivity of PDA toward nucleophilic reactions, enabling facile surface modification for different applications. PDA nanocapsules are nontoxic to mammalian cells while Cu-containing PDA capsules demonstrate strong (99.9%) and rapid (15 min) bactericidal activity.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / toxicity
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Cell Line, Tumor
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Cell Survival / drug effects
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Copper Sulfate / chemistry
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Indoles / chemistry*
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Nanocapsules / chemistry*
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Nanocapsules / toxicity
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Polymers / chemistry*
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Pseudomonas aeruginosa / drug effects
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Rats
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Staphylococcus aureus / drug effects
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Ultrasonics
Substances
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Anti-Bacterial Agents
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Indoles
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Nanocapsules
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Polymers
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polydopamine
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Copper Sulfate