Correlation between Ki67 and breast cancer prognosis

Konstantinos Kontzoglou; Victoria Palla; George Karaolanis; Ioannis Karaiskos; Ioannis Alexiou; Ioannis Pateras; Konstantinos Konstantoudakis; Michael Stamatakos

doi:10.1159/000346475

Correlation between Ki67 and breast cancer prognosis

Oncology. 2013;84(4):219-25. doi: 10.1159/000346475. Epub 2013 Jan 24.

Authors

Konstantinos Kontzoglou¹, Victoria Palla, George Karaolanis, Ioannis Karaiskos, Ioannis Alexiou, Ioannis Pateras, Konstantinos Konstantoudakis, Michael Stamatakos

Affiliation

¹ Second Department of Propaedeutic Surgery, Medical School, University of Athens, Laikon General Hospital, Athens, Greece.

PMID: 23364275
DOI: 10.1159/000346475

Abstract

Background: Ki67 is an immunohistochemical proliferation marker in many types of cancer and has been widely studied among breast cancer patients mostly through retrospective studies.

Methods: The MEDLINE/PubMed database was searched for publications with the medical subject heading 'Ki 67' and the key words 'breast', 'cancer', and 'prognosis'. We restricted our search to articles published until 2012.

Results: In this review, we included 78 articles and abstracts that were accessible and available in English. An effort to further explain the role of Ki67 in the prognosis of breast cancer has been made.

Conclusions: The debate on the prognostic role of Ki67 in breast cancer is still open, although most of the studies have established a relation between Ki67 and overall and disease-free survival. Further research should be made in order to establish Ki67 as a standard prognostic marker in breast cancer.

Publication types

Review

MeSH terms

Biomarkers, Tumor / analysis
Breast Neoplasms / metabolism*
Breast Neoplasms / mortality*
Breast Neoplasms / pathology
Disease-Free Survival
Female
Humans
Ki-67 Antigen / analysis*
Ki-67 Antigen / metabolism*
Predictive Value of Tests
Prognosis

Substances

Biomarkers, Tumor
Ki-67 Antigen