Diabetes mellitus and elevated copeptin levels in middle age predict low cognitive speed after long-term follow-up

Dement Geriatr Cogn Disord. 2013;35(1-2):67-76. doi: 10.1159/000346292. Epub 2013 Jan 29.

Abstract

Background/aims: We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort.

Methods: Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later using the Mini-Mental State Examination (MMSE) and A Quick Test of Cognitive Speed (AQT).

Results: Logistic regression showed that diabetes (OR, 1.86; p < 0.05) and higher copeptin levels (OR, 1.19; p < 0.05) were independently associated with an increased risk of low AQT performance.

Conclusion: Prevalence of diabetes mellitus and elevated copeptin levels in middle age predict lower cognitive speed after long-term follow-up.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Biomarkers / blood
  • Cognition / physiology*
  • Cognition Disorders / metabolism*
  • Cognition Disorders / psychology*
  • Cohort Studies
  • Cystatin C / blood
  • Diabetes Mellitus / metabolism*
  • Educational Status
  • Female
  • Follow-Up Studies
  • Glycopeptides / metabolism*
  • Humans
  • Lipids / blood
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Sweden / epidemiology

Substances

  • Biomarkers
  • Cystatin C
  • Glycopeptides
  • Lipids
  • copeptins