Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii

Wei Zhang; Jeffrey L Fortman; Jacob C Carlson; Jinyong Yan; Yi Liu; Fali Bai; Wenna Guan; Junyong Jia; Teatulohi Matainaho; David H Sherman; Shengying Li

doi:10.1002/cbic.201200743

Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii

Chembiochem. 2013 Feb 11;14(3):301-6. doi: 10.1002/cbic.201200743. Epub 2013 Jan 29.

Authors

Wei Zhang¹, Jeffrey L Fortman, Jacob C Carlson, Jinyong Yan, Yi Liu, Fali Bai, Wenna Guan, Junyong Jia, Teatulohi Matainaho, David H Sherman, Shengying Li

Affiliation

¹ Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao, Shandong 266101, PR China.

Abstract

New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / metabolism
Gene Library
Macrolides / chemistry
Macrolides / metabolism*
Multigene Family
Polyketide Synthases / genetics
Polyketide Synthases / metabolism
Streptomyces / genetics*

Substances

Antifungal Agents
Macrolides
Polyketide Synthases
bafilomycin B1

Abstract

Publication types

MeSH terms

Substances

Grants and funding