Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations

Nat Commun. 2013:4:1412. doi: 10.1038/ncomms2402.

Abstract

Tissue-resident dendritic cells patrol for foreign antigens while undergoing slow mesenchymal migration. Using actomyosin-based structures called podosomes, dendritic cells probe and remodel extracellular matrix topographical cues. Podosomes comprise an actin-rich protrusive core surrounded by an adhesive ring of integrins, cytoskeletal adaptor proteins and actin network filaments. Here we reveal how the integrity and dynamics of protrusive cores and adhesive rings are coordinated by the actomyosin apparatus. Core growth by actin polymerization induces podosome protrusion and provides tension within the actin network filaments. The tension transmitted to the ring recruits vinculin and zyxin and preserves overall podosome integrity. Conversely, myosin IIA contracts the actin network filaments and applies tension to the vinculin molecules bound, counterbalancing core growth and eventually reducing podosome size and protrusion. We demonstrate a previously unrecognized interplay between actin and myosin IIA in podosomes, providing novel mechanistic insights into how actomyosin-based structures allow dendritic cells to sense the extracellular environment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins
  • Cytoplasmic Structures / metabolism*
  • Dendritic Cells / cytology*
  • Dendritic Cells / metabolism*
  • Focal Adhesions / metabolism
  • Green Fluorescent Proteins / metabolism
  • Humans
  • Models, Biological
  • Nonmuscle Myosin Type IIA / metabolism*
  • Polymerization
  • Transfection
  • Vinculin / metabolism
  • Zyxin / metabolism

Substances

  • Actins
  • Zyxin
  • Vinculin
  • Green Fluorescent Proteins
  • Nonmuscle Myosin Type IIA