Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

David Booth; Jacob George

doi:10.1038/ng.2537

Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

Nat Genet. 2013 Feb;45(2):119-20. doi: 10.1038/ng.2537.

Authors

David Booth¹, Jacob George

Affiliation

¹ Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia. jacob.george@sydney.edu.au

PMID: 23358218
DOI: 10.1038/ng.2537

Abstract

Attempts to elucidate the mechanism underpinning the genetic association between IFNL3, previously called IL28B, and clearance of hepatitis C virus have, by and large, been unsuccessful. A study in this issue suggests that a new gene, IFNL4, may be responsible.

Publication types

News

MeSH terms

Hep G2 Cells
Hepatitis C / immunology
Hepatitis C / prevention & control*
Humans
Interleukins / genetics*
Interleukins / immunology
Linkage Disequilibrium
Models, Biological
Phosphorylation
Polymorphism, Genetic / genetics*
STAT1 Transcription Factor / metabolism
STAT2 Transcription Factor / metabolism
Species Specificity

Substances

Interleukins
STAT1 Transcription Factor
STAT2 Transcription Factor