Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

Shravankumar Kankala; Ranjith Kumar Kankala; Prasad Gundepaka; Niranjan Thota; Srinivas Nerella; Mohan Rao Gangula; Hanmanthu Guguloth; Mukkanti Kagga; Ravinder Vadde; Chandra Sekhar Vasam

doi:10.1016/j.bmcl.2012.12.101

Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1306-9. doi: 10.1016/j.bmcl.2012.12.101. Epub 2013 Jan 9.

Authors

Shravankumar Kankala¹, Ranjith Kumar Kankala, Prasad Gundepaka, Niranjan Thota, Srinivas Nerella, Mohan Rao Gangula, Hanmanthu Guguloth, Mukkanti Kagga, Ravinder Vadde, Chandra Sekhar Vasam

Affiliation

¹ Department of Chemistry, Kakatiya University, Warangal, India.

PMID: 23357631
DOI: 10.1016/j.bmcl.2012.12.101

Abstract

Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their efficiency in in vivo analgesic and anti-inflammatory activity was described. A comparison of structure-activity relationship for there compounds was also emphasized.

MeSH terms

Analgesics / chemical synthesis*
Analgesics / pharmacology*
Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / pharmacology*
Benzimidazoles / chemical synthesis*
Benzimidazoles / pharmacology*
Isoxazoles / chemical synthesis*
Isoxazoles / pharmacology*
Structure-Activity Relationship

Substances

Analgesics
Anti-Inflammatory Agents
Benzimidazoles
Isoxazoles
2-mercaptobenzimidazole