The role of miRNA-29 family in cancer

Yang Wang; Xinwei Zhang; Hui Li; Jinpu Yu; Xiubao Ren

doi:10.1016/j.ejcb.2012.11.004

The role of miRNA-29 family in cancer

Eur J Cell Biol. 2013 Mar;92(3):123-8. doi: 10.1016/j.ejcb.2012.11.004. Epub 2013 Jan 26.

Authors

Yang Wang¹, Xinwei Zhang, Hui Li, Jinpu Yu, Xiubao Ren

Affiliation

¹ Department of Oncology, Tianjin Medical University, Tianjin, China. hutu120@sina.com

PMID: 23357522
DOI: 10.1016/j.ejcb.2012.11.004

Abstract

The miRNA-29 family of microRNAs (miRNAs), including miR-29a, miR-29b and miR-29c, was recently reported to be aberrantly expressed in multiple cancers. Increasing evidence shows that the abnormal expression of miR-29 family is associated with tumorigenesis and cancer progression, making miR-29s a well-analyzed group of miRNAs in cancer research. Here, in this review we aim to provide an overview of the role of miR-29 family in the pathophysiologic changes of cancer cells and the epigenetic and immune regulation through the biological function of miR-29s.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Line, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs / biosynthesis
MicroRNAs / genetics*
Neoplasms / genetics*
Neoplasms / metabolism

Substances

MIRN29a microRNA, human
MicroRNAs