Rhodium-catalyzed chemo- and regioselective cross-dimerization of two terminal alkynes

Org Lett. 2013 Feb 15;15(4):840-3. doi: 10.1021/ol303531m. Epub 2013 Jan 28.

Abstract

Cross-dimerization of terminal arylacetylenes and terminal propargylic alcohols/amides has been achieved in the presence of a rhodium catalyst. This method features high chemo- and regioselectivities rendering convenient and atom economical access to functionalized enynes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemical synthesis*
  • Alkynes / chemistry
  • Amides / chemistry*
  • Catalysis
  • Dimerization
  • Molecular Structure
  • Propanols / chemistry*
  • Rhodium / chemistry*
  • Stereoisomerism

Substances

  • Alkynes
  • Amides
  • Propanols
  • Rhodium
  • propargyl alcohol