Palmitoylation, pathogens and their host

Biochem Soc Trans. 2013 Feb 1;41(1):84-8. doi: 10.1042/BST20120337.

Abstract

S-Palmitoylation, the only reversible post-translational lipid modification, confers unique biochemical and functional properties to proteins. Although it has long been known that viral proteins are palmitoylated, recent studies reveal that this modification plays a critical role for pathogens of all kinds and at multiple steps of their life cycle. The present review examines the involvement of S-palmitoylation in infection by viruses, bacteria and parasites and illustrates how pathogens have evolved to manipulate the host palmitoylation machinery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Physiological Phenomena
  • Fungi / physiology
  • Host-Pathogen Interactions*
  • Lipoylation*
  • Palmitic Acid / metabolism*
  • Viral Proteins / metabolism
  • Virus Physiological Phenomena

Substances

  • Viral Proteins
  • Palmitic Acid