Prosthetic valve endocarditis caused by Propionibacterium species successfully treated with coadministered rifampin: report of two cases

Dominique Laurent Braun; Barbara Katharina Hasse; Julia Stricker; Jan Sven Fehr

doi:10.1136/bcr-2012-007204

Prosthetic valve endocarditis caused by Propionibacterium species successfully treated with coadministered rifampin: report of two cases

BMJ Case Rep. 2013 Jan 25:2013:bcr2012007204. doi: 10.1136/bcr-2012-007204.

Authors

Dominique Laurent Braun¹, Barbara Katharina Hasse, Julia Stricker, Jan Sven Fehr

Affiliation

¹ Divison of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. dominique.braun@usz.ch

Abstract

We describe two cases of prosthetic valve endocarditis caused by Propionibacterium spp. successfully treated with a combination of rifampin and intravenous penicillin. Rifampin was chosen due to its promising activity against planktonic and biofilm Propionibacterium, its favourable minimal inhibitory concentrations, its excellent oral bioavailability and tissue penetration.

Publication types

Case Reports

MeSH terms

Actinomycetales Infections / complications
Actinomycetales Infections / drug therapy*
Actinomycetales Infections / microbiology
Aged
Anti-Bacterial Agents / therapeutic use*
Aortic Valve / microbiology
Bioprosthesis / adverse effects*
Bioprosthesis / microbiology
Drug Therapy, Combination
Endocarditis, Bacterial / drug therapy*
Endocarditis, Bacterial / microbiology
Endocarditis, Bacterial / surgery
Female
Heart Valve Prosthesis / adverse effects*
Heart Valve Prosthesis / microbiology
Humans
Male
Middle Aged
Penicillins / therapeutic use
Propionibacterium*
Rifampin / therapeutic use*

Substances

Anti-Bacterial Agents
Penicillins
Rifampin