Labdane diterpenoids and lignans from Calocedrus macrolepis

Fitoterapia. 2013 Mar:85:154-60. doi: 10.1016/j.fitote.2013.01.011. Epub 2013 Jan 23.

Abstract

Three new labdane diterpenoids, calomacrins A-C (1-3), and a new diaryl butyrolactone-type lignan, calomacrol A (8), as well as four known labdane diterpenoids and six known lignans, were isolated from the twigs and leaves of Calocedrus macrolepis. Structures of the new compounds were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. Compounds 3-14 were evaluated for cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / isolation & purification
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Benzodioxoles / chemistry
  • Benzodioxoles / isolation & purification*
  • Cupressaceae / chemistry*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Drug Screening Assays, Antitumor
  • Humans
  • MCF-7 Cells

Substances

  • Antineoplastic Agents, Phytogenic
  • Benzodioxoles
  • Diterpenes
  • 4-Butyrolactone