Worrisome trend of new multiple mechanisms of linezolid resistance in staphylococcal clones diffused in Italy

J Clin Microbiol. 2013 Apr;51(4):1256-9. doi: 10.1128/JCM.00098-13. Epub 2013 Jan 23.

Abstract

In order to assess the frequency of clinically relevant linezolid-resistant staphylococcal isolates, and the role of linezolid in maintaining and coselecting multiple resistance mechanisms (cfr, 23S rRNA, L3/L4 mutations), a prospective Italian study was performed from 2010 to 2011 to confirm the diffusion of three major multidrug-resistant clones (ST2, ST5, ST23).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Bacterial*
  • Genes, Bacterial
  • Humans
  • Italy / epidemiology
  • Linezolid
  • Mutation
  • Oxazolidinones / pharmacology*
  • Prevalence
  • Prospective Studies
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology*
  • Staphylococcus / drug effects*
  • Staphylococcus / isolation & purification

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid