SnO(2)-ZnSn(OH)(6): a novel binary affinity probe for global phosphopeptide detection

Chem Commun (Camb). 2013 Feb 28;49(17):1762-4. doi: 10.1039/c3cc38909j.

Abstract

ZnSn(OH)(6) and binary-component SnO(2)-ZnSn(OH)(6) were introduced as affinity probes for phosphopeptide enrichment for the first time. Two strategies, either ZnSn(OH)(6) and SnO(2) serial enrichment or binary-component SnO(2)-ZnSn(OH)(6) enrichment in a single run, were proposed to enhance multi-phosphopeptide enrichment and to significantly improve global phosphopeptide detection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Caseins / metabolism
  • Phosphopeptides / analysis*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*
  • Tin Compounds / chemistry*
  • Trypsin / metabolism
  • Zinc / chemistry*

Substances

  • Caseins
  • Phosphopeptides
  • Tin Compounds
  • Trypsin
  • Zinc
  • stannic oxide