Anti-inflammatory lignans from the fruits of Acanthopanax sessiliflorus

Molecules. 2012 Dec 21;18(1):41-9. doi: 10.3390/molecules18010041.

Abstract

A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Cell Survival / drug effects
  • Eleutherococcus / chemistry*
  • Fruit / chemistry*
  • Inhibitory Concentration 50
  • Lignans / pharmacology*
  • Lipopolysaccharides
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Magnetic Resonance Spectroscopy
  • Mice
  • Nitric Oxide / metabolism
  • Plant Extracts / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Lignans
  • Lipopolysaccharides
  • Plant Extracts
  • acanthosessilin A
  • Nitric Oxide