Abstract
A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Eleutherococcus / chemistry*
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Fruit / chemistry*
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Inhibitory Concentration 50
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Lignans / pharmacology*
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Lipopolysaccharides
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Macrophages / drug effects
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Macrophages / metabolism
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Magnetic Resonance Spectroscopy
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Mice
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Nitric Oxide / metabolism
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Plant Extracts / pharmacology*
Substances
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Anti-Inflammatory Agents
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Lignans
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Lipopolysaccharides
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Plant Extracts
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acanthosessilin A
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Nitric Oxide