Review of drugs for Alzheimer's disease

Drug Discov Ther. 2012 Dec;6(6):285-90.

Abstract

Alzheimer's disease (AD) is the most common form of dementia in the elderly. The number of people affected by AD is rapidly increasing. AD is characterized by cerebral atrophy, cerebral senile plaques, intraneuronal neurofibrillary tangles, and neuronal cell loss. Medical treatment of AD has a long history and differing results. We will review the effectiveness and limitations of the drugs used to treat AD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / etiology
  • Amino Acid Sequence
  • Amyloid beta-Peptides / antagonists & inhibitors
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / immunology
  • Amyloid beta-Peptides / physiology
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Cholinesterase Inhibitors / therapeutic use
  • Humans
  • Immunization
  • Molecular Sequence Data
  • Parasympathetic Nervous System / drug effects
  • Parasympathetic Nervous System / physiopathology

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Cholinesterase Inhibitors