Objective: The objective of this study was to examine the effectiveness of 2 products on venous ulcer periwound skin.
Design: This was a descriptive comparative study.
Setting: An outpatient wound care clinic in a rural Midwestern area of the United States.
Participants: Participants included a retrospective group of 50 patients and a prospective group of 28 patients.
Intervention: The intervention compared the experimental product (Remedy Nutrashield; Medline Industries, Mundelein, Illinois) versus Cavilon Moisturizing Lotion (3M, St Paul, Minnesota).
Outcome measures: The mean outcome measures were a decrease in periwound and ulcer size.
Main results: For the periwound size, the estimated rates of change were as follows: 0.092 (SE, 0.021) cm/d and -0.026 (SE, 0.014) cm/d for products B and A groups, respectively. The decrease for the experimental group was significantly greater than the attenuated decrease for the retrospective cases (t297 = -2.57, P = .01), and the decrease for product B group was also significantly different from zero (t76 = -4.34, P < .0001). For the ulcer size model, the estimated rates of change were -0.272 (SE, 0.102) cm/d and -0.130 (SE, 0.067) cm/d for the experimental and retrospective groups, respectively. The rate for the experimental group was significantly less than zero (t76 = -2.67, P = .009), but there was no significant difference between prospective and retrospective cases in the rates of reduction in ulcer size (t308 = -1.16, P = .25).
Conclusion: The results of this study illustrate how the integrity of the periwound skin may be an important determinant in decreasing periwound and ulcer size.