Unspliced XBP1 controls autophagy through FoxO1

Cell Res. 2013 Apr;23(4):463-4. doi: 10.1038/cr.2013.9. Epub 2013 Jan 22.

Abstract

Protein homeostasis in higher eukaryotes is balanced by a dynamic network of adaptive mechanisms, including the unfolded protein response (UPR) and autophagy. In a paper recently published in Cell Research, Zhu and co-workers uncover a novel biological function of the unspliced form of the UPR transcription factor XBP1 in the modulation of autophagy through the control of FoxO1 turnover.

Publication types

  • Comment

MeSH terms

  • DNA-Binding Proteins / genetics*
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors / genetics*
  • Gene Expression Regulation, Neoplastic*
  • Glutamine / deficiency*
  • Humans
  • Regulatory Factor X Transcription Factors
  • Transcription Factors / genetics*
  • X-Box Binding Protein 1

Substances

  • DNA-Binding Proteins
  • FOXO1 protein, human
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Regulatory Factor X Transcription Factors
  • Transcription Factors
  • X-Box Binding Protein 1
  • XBP1 protein, human
  • Glutamine