A new triterpenoid from Teucrium viscidum

Molecules. 2013 Jan 21;18(1):1262-9. doi: 10.3390/molecules18011262.

Abstract

A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1-4 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 11-beta-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*
  • 11-beta-Hydroxysteroid Dehydrogenases / metabolism
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • HEK293 Cells
  • Humans
  • Liquid-Liquid Extraction
  • Microsomes / drug effects
  • Microsomes / enzymology
  • Molecular Structure
  • Structure-Activity Relationship
  • Teucrium / chemistry*
  • Triterpenes / isolation & purification*

Substances

  • Drugs, Chinese Herbal
  • Enzyme Inhibitors
  • Triterpenes
  • 11-beta-Hydroxysteroid Dehydrogenases