Modulation of neutrophil oxidative burst via histamine receptors

Br J Pharmacol. 2013 Sep;170(1):17-22. doi: 10.1111/bph.12107.

Abstract

Histamine has the ability to influence the activity of immune cells including neutrophils and plays a pivotal role in inflammatory processes, which are a complex network of cellular and humoral events. One of the main functions manifested by activated neutrophils is oxidative burst, which is linked to the production of reactive oxygen species; therefore, the effects of histamine receptor agonists and antagonists on the oxidative burst of neutrophils is reviewed. A role for the well-characterized histamine H1 and H2 receptors in this process is discussed and compared to that of the recently discovered H4 receptor.

Keywords: histamine; histamine receptor; neutrophil; oxidative burst; reactive oxygen species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Histamine / metabolism
  • Histamine Agonists / pharmacology*
  • Histamine Antagonists / pharmacology*
  • Humans
  • Inflammation / metabolism
  • Neutrophils / metabolism
  • Reactive Oxygen Species / metabolism
  • Receptors, G-Protein-Coupled / drug effects*
  • Receptors, G-Protein-Coupled / metabolism
  • Receptors, Histamine / drug effects*
  • Receptors, Histamine / metabolism
  • Receptors, Histamine H1 / drug effects
  • Receptors, Histamine H1 / metabolism
  • Receptors, Histamine H2 / drug effects
  • Receptors, Histamine H2 / metabolism
  • Receptors, Histamine H4
  • Respiratory Burst / drug effects

Substances

  • HRH4 protein, human
  • Histamine Agonists
  • Histamine Antagonists
  • Reactive Oxygen Species
  • Receptors, G-Protein-Coupled
  • Receptors, Histamine
  • Receptors, Histamine H1
  • Receptors, Histamine H2
  • Receptors, Histamine H4
  • Histamine