Abstract
Histamine has the ability to influence the activity of immune cells including neutrophils and plays a pivotal role in inflammatory processes, which are a complex network of cellular and humoral events. One of the main functions manifested by activated neutrophils is oxidative burst, which is linked to the production of reactive oxygen species; therefore, the effects of histamine receptor agonists and antagonists on the oxidative burst of neutrophils is reviewed. A role for the well-characterized histamine H1 and H2 receptors in this process is discussed and compared to that of the recently discovered H4 receptor.
Keywords:
histamine; histamine receptor; neutrophil; oxidative burst; reactive oxygen species.
© 2013 The Authors. British Journal of Pharmacology © 2013 The British Pharmacological Society.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Histamine / metabolism
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Histamine Agonists / pharmacology*
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Histamine Antagonists / pharmacology*
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Humans
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Inflammation / metabolism
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Neutrophils / metabolism
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Reactive Oxygen Species / metabolism
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Receptors, G-Protein-Coupled / drug effects*
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Receptors, G-Protein-Coupled / metabolism
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Receptors, Histamine / drug effects*
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Receptors, Histamine / metabolism
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Receptors, Histamine H1 / drug effects
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Receptors, Histamine H1 / metabolism
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Receptors, Histamine H2 / drug effects
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Receptors, Histamine H2 / metabolism
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Receptors, Histamine H4
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Respiratory Burst / drug effects
Substances
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HRH4 protein, human
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Histamine Agonists
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Histamine Antagonists
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Reactive Oxygen Species
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Receptors, G-Protein-Coupled
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Receptors, Histamine
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Receptors, Histamine H1
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Receptors, Histamine H2
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Receptors, Histamine H4
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Histamine