Abstract
A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation is described. This protocol provides efficient access to a range of ortho-acyl phenylacetamides, which can be easily converted to 3-isochromanone derivatives.
MeSH terms
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Acetamides / chemistry*
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Acylation
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Carboxylic Acids / chemistry*
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Catalysis
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Chromones / chemical synthesis*
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Chromones / chemistry
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Decarboxylation
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Molecular Structure
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Organometallic Compounds / chemistry*
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Palladium / chemistry*
Substances
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Acetamides
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Carboxylic Acids
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Chromones
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Organometallic Compounds
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Palladium