The impact of passive hyperthermia on human attention networks: an fMRI study

Abstract

An attention network test (ANT) provides a behavioral measure of the efficiency of the three attention networks (alerting, orienting and executive networks) within a single task. In the present study, we investigated the effect of passive hyperthermia on the attention network with event-related functional magnetic resonance imaging (fMRI). The behavioral results showed that passive hyperthermia of 50 °C and 40% relative humidity impaired the executive function, but showed no effect on the alerting and orienting networks. The fMRI results showed that: (i) passive hyperthermia enhanced the activity in the right superior frontal gyrus and depressed the activity in the right middle occipital gyrus, left inferior parietal lobule and left culmen in the alerting network, (ii) passive hyperthermia enhanced the activity in the temporal lobe and depressed the activity in the frontal lobe, parietal lobe and occipital lobe in the orienting network, and (iii) passive hyperthermia enhanced the activity in the dorsolateral prefrontal cortex but did not affect the activity in the anterior cingulate. We concluded that passive hyperthermia impaired executive function, especially the efficiency of resolving conflict and the negative effects of passive hyperthermia on alerting and orienting were overcome through variant regional brain activation.