Differential responses of adiposity, inflammation and autonomic function to aerobic versus resistance training in older adults

Exp Gerontol. 2013 Mar;48(3):326-33. doi: 10.1016/j.exger.2013.01.002. Epub 2013 Jan 17.

Abstract

Background: Increased body fat, autonomic dysfunction and low-grade chronic inflammation are interrelated risk factors implicated in the etiology of several chronic conditions normally presented by older adults.

Objective: This study aims to assess the effectiveness of different training protocols on reducing body fat, improving autonomic function, and decreasing low-grade systemic inflammation in community-dwelling elderly adults.

Methods: Fifty participants (11 men, 68±5.5years) were randomly allocated into resistance or aerobic training or control groups. Evaluations were done at baseline and following the 8-month intervention period on their body composition (assessed by DXA), inflammatory biomarkers (high-sensitivity C-reactive protein [hs-CRP], tumor necrosis-alpha [TNF-α], interferon-gamma [IFN-γ], interleukins-6 and -10 [IL-6, IL-10]), lipoproteic profile, fasting glycemia, blood pressure, heart rate variability (HRV; frequency and time domains) and aerobic fitness (assessed by six-minute walk distance [6MWD]). A paired t-test was used to detect changes (%Δ=[(post-test score-pretest score)/pre-test score]×100) within groups, while between-group differences were analyzed using the one-way ANOVA or General Linear Models.

Results: A significant change (Δ%) both in total (-5.4±6.3% and -3.3±2.9%, respectively) and central body fat (8.9±11.3% and -4.8±4.5%) was observed in resistance and aerobic training groups, respectively; along with a change in resting systolic and diastolic blood pressures (-9.2±9.8% and -8.5±9.6%), heart rate (-4.6±6.5%), hs-CRP (-18.6±60.6%), and 6MWD (9.5±6.9%) in response to aerobic training.

Conclusions: The present findings provide further evidence for the benefits of aerobic and resistance training on reducing body fat. Aerobic training was demonstrated to reduce hs-CRP and blood pressure in community-dwelling elderly participants with no serious medical conditions.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity / physiology*
  • Aged
  • Aged, 80 and over
  • Autonomic Nervous System Diseases / blood
  • Autonomic Nervous System Diseases / physiopathology
  • Autonomic Nervous System Diseases / rehabilitation*
  • Blood Pressure / physiology
  • Body Composition / physiology
  • C-Reactive Protein / metabolism
  • Exercise Therapy / methods*
  • Female
  • Heart Rate / physiology
  • Humans
  • Inflammation / blood
  • Inflammation / physiopathology
  • Inflammation / rehabilitation*
  • Inflammation Mediators / blood
  • Male
  • Middle Aged
  • Resistance Training / methods

Substances

  • Inflammation Mediators
  • C-Reactive Protein