Expression of antiangiogenic factors in the placental structures in pre-eclampsia

A I Shchyogolev; E A Dubova; K A Pavlova; V M Lyapin; G T Sukhikh

doi:10.1007/s10517-012-1932-0

Expression of antiangiogenic factors in the placental structures in pre-eclampsia

Bull Exp Biol Med. 2012 Dec;154(2):287-91. doi: 10.1007/s10517-012-1932-0.

Authors

A I Shchyogolev¹, E A Dubova, K A Pavlova, V M Lyapin, G T Sukhikh

Affiliation

¹ V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. ashegolev@oparina4.ru

PMID: 23330145
DOI: 10.1007/s10517-012-1932-0

Abstract

Comparative morphological study of the placentas was carried out in women with pregnancy aggravated by the development of pre-eclampsia. Immunohistochemical methods showed increased expression of endoglin (CD105) and VEGFR1 in all placental structures. The intensity of endoglin and VEGFR1 expression was maximum in the syncytiotrophoblast and extravillous cytotrophoblast cells in severe pre-eclampsia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antigens, CD / metabolism*
Endoglin
Female
Humans
Placenta / metabolism*
Pre-Eclampsia / metabolism*
Pregnancy
Receptors, Cell Surface / metabolism*
Trophoblasts / metabolism
Vascular Endothelial Growth Factor Receptor-1 / metabolism*

Substances

Antigens, CD
ENG protein, human
Endoglin
Receptors, Cell Surface
Vascular Endothelial Growth Factor Receptor-1