Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis

E S Tanigina; A V Semenikhina; T N Popova; L V Matasova; E D Kryl'skiy

doi:10.1007/s10517-012-1909-z

Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis

Bull Exp Biol Med. 2012 Dec;154(2):192-5. doi: 10.1007/s10517-012-1909-z.

Authors

E S Tanigina¹, A V Semenikhina, T N Popova, L V Matasova, E D Kryl'skiy

Affiliation

¹ Department of Medical Biochemistry and Microbiology, Voronezh State University, Russia.

PMID: 23330122
DOI: 10.1007/s10517-012-1909-z

Abstract

Administration of 3,5-dicarbomethoxyphenylbiguanide to rats with experimental epinephrine-induced myocarditis was followed by a decrease in activity of marker enzymes for cardiomyocyte cytolysis in the blood serum. This agent also decreased the intensity of free radical processes and had a normalizing effect on aconitase activity in the heart and blood serum of rats with myocarditis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biguanides / chemistry*
Biguanides / therapeutic use*
Cardiotonic Agents / chemistry*
Cardiotonic Agents / therapeutic use*
Free Radicals / metabolism*
Homeostasis / drug effects
Male
Myocarditis / drug therapy*
Myocarditis / metabolism*
Rats

Substances

Biguanides
Cardiotonic Agents
Free Radicals
phenyl biguanide