Precocious puberty produced by an osteolipoma of the tuber cinereum

J Pediatr Endocrinol Metab. 2012;25(11-12):1165-8. doi: 10.1515/jpem-2012-0192.

Abstract

Central precocious puberty (CPP) is fairly common in girls. In most girls, the etiology for the CPP is unknown. Among the more rare causes of CPP in girls are central nervous system tumors and hamartomas. Osteolipoma of the tuber cinereum, which is the most commonly diagnosed at autopsy, has been reported as a cause of CPP. We describe an 8-year-old girl with central precocious puberty in whom MRI demonstrated a lesion compatible with osteolipoma. Her symptom was breast development that begun at age 7 years and 9 months. Her case history, laboratory studies and imaging are presented. Her puberty was rapidly progressive. She was treated successfully with a GnRHa (Triptorelin 3.75 mg IM q 4 weeks). Her case brings to the forefront the need to perform an MRI in children with rapidly progressing puberty.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / diagnosis
  • Algorithms
  • Child
  • Diagnosis, Differential
  • Female
  • Fibrous Dysplasia of Bone / diagnosis
  • Gonadotropin-Releasing Hormone / analogs & derivatives
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Humans
  • Hypothalamic Neoplasms / complications
  • Hypothalamic Neoplasms / diagnosis*
  • Hypothalamic Neoplasms / drug therapy
  • Lipoma / complications
  • Lipoma / diagnosis*
  • Lipoma / drug therapy
  • Magnetic Resonance Imaging
  • Ovarian Cysts / diagnosis
  • Ovarian Neoplasms / diagnosis
  • Puberty, Precocious / diagnosis*
  • Puberty, Precocious / drug therapy
  • Puberty, Precocious / etiology
  • Treatment Outcome
  • Tuber Cinereum / pathology*

Substances

  • Gonadotropin-Releasing Hormone
  • LHRH, Ala(6)-Gly(10)-ethylamide-