Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Nigel J Pyne; Susan Pyne

doi:10.1016/j.ccr.2012.12.005

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Cancer Cell. 2013 Jan 14;23(1):5-7. doi: 10.1016/j.ccr.2012.12.005.

Authors

Nigel J Pyne¹, Susan Pyne

Affiliation

¹ Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. n.j.pyne@strath.ac.uk

PMID: 23328479
DOI: 10.1016/j.ccr.2012.12.005

Abstract

In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-κB/IL-6/STAT3 pathway. This appears critical for progression from chronic inflammation to colon cancer.

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