Synthesis of bisindolylmethanes and their cytotoxicity properties

Kalla Reddi Mohan Naidu; Shaik Ibrahim Khalivulla; Syed Rasheed; Sharida Fakurazi; Palanisamy Arulselvan; Ola Lasekan; Faridah Abas

doi:10.3390/ijms14011843

Synthesis of bisindolylmethanes and their cytotoxicity properties

Int J Mol Sci. 2013 Jan 16;14(1):1843-53. doi: 10.3390/ijms14011843.

Authors

Kalla Reddi Mohan Naidu¹, Shaik Ibrahim Khalivulla, Syed Rasheed, Sharida Fakurazi, Palanisamy Arulselvan, Ola Lasekan, Faridah Abas

Affiliation

¹ Department of Food Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. lasekan@food.upm.edu.my.

Abstract

Polymer supported dichlorophosphate (PEG-OPOCl(2)) is an efficient green catalyst for the electrophilic substitution reaction of indole with aromatic aldehydes, in neat condition, to afford an excellent yield of bis(indolyl) methanes with short reaction time, at room temperature. The synthesized compounds and their anti-cancer activity are evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents* / chemical synthesis
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Cytotoxins* / chemical synthesis
Cytotoxins* / chemistry
Cytotoxins* / pharmacology
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Indoles* / chemical synthesis
Indoles* / chemistry
Indoles* / pharmacology

Substances

Antineoplastic Agents
Cytotoxins
Indoles