A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration

J Asian Nat Prod Res. 2013;15(2):203-8. doi: 10.1080/10286020.2012.751977. Epub 2013 Jan 17.

Abstract

A new 2,5-diketopiperazine, (R)-2-(2-(furan-2-yl)-oxoethyl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione, and seven known compounds were isolated from the ethyl acetate extract of liquid fermentation broth of Armillaria mellea. The structures of the isolated compounds were established from NMR and HR-MS data. The absolute configuration of the new compound was established by comparing the experimental electronic circular dichroism (ECD) spectrum with the calculated ECD data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Armillaria / chemistry*
  • Circular Dichroism
  • Diketopiperazines / chemistry
  • Diketopiperazines / isolation & purification*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Fermentation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Stereoisomerism

Substances

  • (R)-2-(2-(furan-2-yl)-oxoethyl)octahydropyrrolo(1,2-a)pyrazine-1,4-dione
  • Diketopiperazines
  • Drugs, Chinese Herbal