An efficient synthesis of optically active trifluoromethyl aldimines via asymmetric biomimetic transamination

Chem Commun (Camb). 2013 Feb 18;49(14):1404-6. doi: 10.1039/c2cc37423d.

Abstract

This communication describes a chiral base-catalyzed asymmetric [1,3]-proton shift of trifluoromethyl ketimines, giving a wide variety of trifluoromethyl aldimines containing various functional groups with up to 94% ee.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination
  • Amines / chemistry
  • Biomimetic Materials / chemistry*
  • Catalysis
  • Crystallography, X-Ray
  • Imines / chemistry*
  • Molecular Conformation
  • Nitriles / chemistry*
  • Protons
  • Stereoisomerism

Substances

  • Amines
  • Imines
  • Nitriles
  • Protons
  • ketimine