High prevalence of antibiotic resistance and molecular characterization of integrons among Shigella isolates in Eastern China

Antimicrob Agents Chemother. 2013 Mar;57(3):1549-51. doi: 10.1128/AAC.02102-12. Epub 2013 Jan 14.

Abstract

A total of 747 Shigella isolates were collected from hospitals in Jiangsu Province of China. Susceptibilities to antimicrobials and integrons were tested. A total of 78.3% of S. flexneri isolates and a total of 74.3% S. sonei isolates were resistant to at least three antibiotics. Of the Shigella isolates, 74.7% had integron I and 82.6% had integron II. The conjunction of the high prevalence of integrons in Shigella and high resistance to antimicrobials will lead to rapid dissemination of resistant genes in this region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Child, Preschool
  • China / epidemiology
  • DNA, Bacterial / genetics*
  • DNA, Bacterial / isolation & purification
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Dysentery, Bacillary / drug therapy
  • Dysentery, Bacillary / epidemiology
  • Dysentery, Bacillary / microbiology
  • Dysentery, Bacillary / transmission*
  • Feces / microbiology
  • Female
  • Humans
  • Infant
  • Integrons / genetics*
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Prevalence
  • Shigella flexneri / drug effects
  • Shigella flexneri / genetics*
  • Shigella flexneri / isolation & purification
  • Shigella sonnei / drug effects
  • Shigella sonnei / genetics*
  • Shigella sonnei / isolation & purification

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial