Abstract
High-risk human papillomavirus (HPV) especially HPV-16 and HPV-18 types are speculated to be important risk factors in non-smoking associated lung cancer in Asia. Increasing evidence has demonstrated that HPV oncoproteins may contribute to lung tumorigenesis and cell transformation. Importantly, HPV 16/18 E6 and E7 oncoproteins can mediate expression of multiple target genes and proteins, such as p53/pRb, VEGF, HIF-1α, cIAP-2, and hTERT, and contribute to cell proliferation, angiogenesis and cell immortalization through different signaling pathways in lung cancer. This article provides an overview of experiment data on HPV-associated lung cancer, describes the main targets on which HPV E6/E7 oncoproteins act, and further discusses the potential signaling pathways in which HPV E6/E7 oncoproteins are involved. In addition, we also raise questions regarding existing problems with the study of HPV-associated lung cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use*
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Cell Transformation, Viral / drug effects*
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DNA-Binding Proteins / antagonists & inhibitors*
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DNA-Binding Proteins / metabolism
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Humans
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / metabolism
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Lung Neoplasms / virology
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Oncogene Proteins, Viral / antagonists & inhibitors*
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Oncogene Proteins, Viral / metabolism
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Papillomaviridae / drug effects
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Papillomaviridae / genetics
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Papillomavirus E7 Proteins / antagonists & inhibitors*
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Papillomavirus E7 Proteins / metabolism
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Repressor Proteins / antagonists & inhibitors*
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Repressor Proteins / metabolism
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Smoking
Substances
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Antineoplastic Agents
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DNA-Binding Proteins
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E6 protein, Human papillomavirus type 16
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E6 protein, Human papillomavirus type 18
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E7 protein, Human papillomavirus type 18
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Oncogene Proteins, Viral
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Papillomavirus E7 Proteins
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Repressor Proteins
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oncogene protein E7, Human papillomavirus type 16