Abstract
Peripheral lymphadenopathy is a rare presentation in malignant mesothelioma. We describe a unique case of malignant mesothelioma arising in an 11-year-old boy, for whom peripheral lymphadenopathy was the initial manifestation of the disease. The final diagnosis was confirmed by a broad panel of immunohistochemical markers. Literature review disclosed only 2 cases in childhood that initially presented with peripheral lymphadenopathy. Pathologists should be aware of this rare biologic behavior of malignant mesothelioma to reach the correct and prompt diagnosis.
Copyright © 2013 Elsevier Inc. All rights reserved.
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Antineoplastic Agents / therapeutic use
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Biomarkers, Tumor / metabolism
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Child
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Diagnosis, Differential
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Humans
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Lung Neoplasms / diagnosis*
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Lung Neoplasms / drug therapy
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Lung Neoplasms / metabolism
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Lymph Nodes / metabolism
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Lymph Nodes / pathology*
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Lymphatic Diseases / diagnosis*
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Lymphatic Diseases / metabolism
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Male
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Mesothelioma / diagnosis*
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Mesothelioma / drug therapy
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Mesothelioma / metabolism
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Mesothelioma, Malignant
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Peritoneal Neoplasms / diagnosis*
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Peritoneal Neoplasms / drug therapy
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Peritoneal Neoplasms / metabolism
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Biomarkers, Tumor