Endogenous CETP activity as a predictor of cardiovascular risk: determination of the optimal range

Atherosclerosis. 2013 Mar;227(1):165-71. doi: 10.1016/j.atherosclerosis.2012.12.024. Epub 2013 Jan 2.

Abstract

Objectives: To identify key determinants of plasma endogenous CETP activity and threshold value of plasma CETP activity associated with high cardiovascular risk.

Methods: Endogenous plasma CETP activity was measured in a total of 1403 individuals.

Results: Multivariate analysis revealed that 23.5% of endogenous CETP activity variability was explained by plasma LDL-C (12.0%), HDL-C (6.4%) and TG (4.4%) whereas sex and BMI accounted together for only 0.7% of its variability. Scoring patients for cardiovascular risk on the basis of their plasma lipid levels (TC, TG, LDL-C and HDL-C), revealed that patients with high cardiovascular risk (score ≥3) displayed a mean endogenous plasma CETP activity above 34%.

Conclusion: Plasma CETP activity represents a potent indicator of cardiovascular risk in patients with metabolic disorders since it integrates major independent risk factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cardiovascular Diseases / etiology*
  • Cholesterol Ester Transfer Proteins / blood*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Triglycerides / blood

Substances

  • Cholesterol Ester Transfer Proteins
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides