Ras GTPases: codon bias holds KRas down but not out

Brian O Bodemann; Michael A White

doi:10.1016/j.cub.2012.11.054

Ras GTPases: codon bias holds KRas down but not out

Curr Biol. 2013 Jan 7;23(1):R17-20. doi: 10.1016/j.cub.2012.11.054.

Authors

Brian O Bodemann¹, Michael A White

Affiliation

¹ Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA.

PMID: 23305663
DOI: 10.1016/j.cub.2012.11.054

Abstract

Rare codons selectively limit the accumulation of Ras family member proteins with important consequences for Ras pathway activation and tumorigenesis.

Publication types

Comment

MeSH terms

Cell Transformation, Neoplastic / genetics*
Codon*
Genes, ras*
Humans
Proto-Oncogene Proteins / chemistry*
Proto-Oncogene Proteins p21(ras)
ras Proteins / chemistry*

Substances

Codon
KRAS protein, human
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
ras Proteins