Abstract
Three enterobacterial isolates (two Klebsiella pneumoniae and one Escherichia coli) were recovered from three patients transferred from India to France in 2011. All three isolates were resistant or of intermediate susceptibility to all β-lactams and of decreased susceptibility to carbapenems. These three isolates expressed a novel carbapenem-hydrolysing β-lactamase, OXA-232, differing from OXA-181 and OXA-48 by one and five amino acid substitutions, respectively. Compared with OXA-181, OXA-232 had a lower ability to hydrolyse carbapenems but conversely possessed higher hydrolytic activities against penicillins. The bla(OXA-232) gene was located on a 6.1-kb ColE-type non-conjugative plasmid.
Copyright © 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Carbapenems / metabolism*
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Carbapenems / pharmacology
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Enterobacteriaceae / classification
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Enterobacteriaceae / drug effects
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / isolation & purification
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Escherichia coli / drug effects
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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France
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Humans
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India
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Phylogeny
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Polymerase Chain Reaction
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Sequence Analysis, DNA
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beta-Lactam Resistance*
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beta-Lactamases* / chemistry
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beta-Lactamases* / genetics
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beta-Lactamases* / metabolism
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Carbapenems
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beta-Lactams
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beta-Lactamases