Abstract
A copper-catalyzed decarboxylative trifluoromethylation of various α,β-unsaturated carboxylic acids by using a stable and inexpensive solid, sodium trifluoromethanesulfinate (CF(3)SO(2)Na, Langlois reagent), was developed. In addition, an iron-catalyzed difluoromethylation of aryl-substituted acrylic acids by using zinc difluoromethanesulfinate (DFMS, (CF(2)HSO(2))(2)Zn, Baran reagent) via a similar radical process was also achieved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / chemistry
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Carboxylic Acids / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Copper / chemistry*
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Hydrocarbons, Fluorinated / chemical synthesis*
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Hydrocarbons, Fluorinated / chemistry
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Indicators and Reagents
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Iron / chemistry*
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Molecular Structure
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Stereoisomerism
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Zinc / chemistry
Substances
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Alkenes
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Carboxylic Acids
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Hydrocarbons, Fluorinated
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Indicators and Reagents
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Copper
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Iron
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Zinc