The heart in diabetes mellitus. Part I. Biochemical basis for myocardial dysfunction

S Afr Med J. 1979 Aug 11;56(6):207-11.

Abstract

The heart in acutely diabetic animals is subject to multiple inhibitions of glucose metabolism caused by enhanced metabolism of free fatty acids (FFA) and ketone bodies. Such metabolic changes may impair the reaction of the diabetic heart to oxygen lack. In chronically diabetic hearts the increased deposition of triglycerides in the heart and the formation of glycoproteins may underlie the newly recognized clinical entity of diabetic cardiomyopathy.

Publication types

  • Review

MeSH terms

  • Alcoholism / complications
  • Animals
  • Carbohydrate Metabolism
  • Cardiomyopathies / etiology
  • Cardiomyopathies / metabolism
  • Coronary Disease / etiology
  • Cyclic AMP / metabolism
  • Diabetes Complications*
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / pathology
  • Diabetic Neuropathies / etiology
  • Dogs
  • Fatty Acids, Nonesterified / metabolism
  • Glucose / metabolism*
  • Heart Diseases / etiology*
  • Heart Diseases / metabolism
  • Heart Diseases / pathology
  • Humans
  • Lipid Metabolism
  • Muscle Proteins / metabolism
  • Myocardium / metabolism*
  • Oxygen Consumption
  • Rats

Substances

  • Fatty Acids, Nonesterified
  • Muscle Proteins
  • Cyclic AMP
  • Glucose