Himeic acids E-G, new 4-pyridone derivatives from a culture of Aspergillus sp

Chem Pharm Bull (Tokyo). 2013;61(1):105-7. doi: 10.1248/cpb.c12-00800.

Abstract

Three new himeic acids E-G were isolated from a marine-derived fungus, Aspergillus sp., and their structures were determined by spectroscopic analysis. Although himeic acid A inhibited the activity of ubiquitin-activating enzyme (E1), the three new derivatives did not.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus / chemistry*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology
  • Fatty Acids, Unsaturated / chemistry*
  • Fatty Acids, Unsaturated / isolation & purification
  • Fatty Acids, Unsaturated / pharmacology
  • Pyridones / chemistry*
  • Pyridones / isolation & purification
  • Pyridones / pharmacology
  • Pyrones / pharmacology
  • Ubiquitin-Activating Enzymes / antagonists & inhibitors*

Substances

  • Enzyme Inhibitors
  • Fatty Acids, Unsaturated
  • Pyridones
  • Pyrones
  • himeic acid A
  • 4-pyridone
  • Ubiquitin-Activating Enzymes