Abstract
Three new himeic acids E-G were isolated from a marine-derived fungus, Aspergillus sp., and their structures were determined by spectroscopic analysis. Although himeic acid A inhibited the activity of ubiquitin-activating enzyme (E1), the three new derivatives did not.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspergillus / chemistry*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Fatty Acids, Unsaturated / chemistry*
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Fatty Acids, Unsaturated / isolation & purification
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Fatty Acids, Unsaturated / pharmacology
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Pyridones / chemistry*
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Pyridones / isolation & purification
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Pyridones / pharmacology
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Pyrones / pharmacology
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Ubiquitin-Activating Enzymes / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Fatty Acids, Unsaturated
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Pyridones
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Pyrones
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himeic acid A
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4-pyridone
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Ubiquitin-Activating Enzymes