Abstract
The antischistosomal effect of two [(η(6)-praziquantel)Cr(CO)(3)] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Chromium / chemistry*
-
Chromium / pharmacology*
-
Coordination Complexes / chemistry*
-
Coordination Complexes / pharmacology*
-
Molecular Structure
-
Praziquantel / chemistry*
-
Praziquantel / pharmacology*
-
Praziquantel / therapeutic use*
-
Schistosoma mansoni / drug effects*
-
Schistosomicides / chemistry*
-
Schistosomicides / pharmacology*
-
Schistosomicides / therapeutic use*
-
Stereoisomerism
Substances
-
(eta(6)-praziquantel)Cr(CO)3
-
Coordination Complexes
-
Schistosomicides
-
Chromium
-
Praziquantel