[(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity

Chemistry. 2013 Feb 11;19(7):2232-5. doi: 10.1002/chem.201204291. Epub 2013 Jan 7.

Abstract

The antischistosomal effect of two [(η(6)-praziquantel)Cr(CO)(3)] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromium / chemistry*
  • Chromium / pharmacology*
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacology*
  • Molecular Structure
  • Praziquantel / chemistry*
  • Praziquantel / pharmacology*
  • Praziquantel / therapeutic use*
  • Schistosoma mansoni / drug effects*
  • Schistosomicides / chemistry*
  • Schistosomicides / pharmacology*
  • Schistosomicides / therapeutic use*
  • Stereoisomerism

Substances

  • (eta(6)-praziquantel)Cr(CO)3
  • Coordination Complexes
  • Schistosomicides
  • Chromium
  • Praziquantel