Depth probing of diffuse tissues controlled with elliptically polarized light

J Biomed Opt. 2013 Jan;18(1):16007. doi: 10.1117/1.JBO.18.1.016007.

Abstract

Polarization gating is a popular technique in biomedical optics. It is widely used to inspect the surface of the tissues (under colinear or cocircular detection) or instead to probe the volume (cross-linear detection), without information on the probed depth. Elliptical polarization is introduced to explore the possibility of probing diffuse tissues at selective depths. A thorough Monte Carlo simulation study shows complete correlation between the probed depths and the ellipticity of the polarized light, for a medium with known optical properties. Within a wide range of optical parameters, a linear relation between the backscattered intensity and the depth extension of the probed volume was found whatever the polarization used, but with a controlled extension depending on the ellipticity.

MeSH terms

  • Animals
  • Brain Chemistry
  • Computer Simulation
  • Diagnostic Imaging / methods*
  • Female
  • Humans
  • Monte Carlo Method
  • Scattering, Radiation
  • Skin / chemistry
  • Swine
  • Uterus / chemistry