High prevalence of fluoroquinolone-resistant group B streptococci among clinical isolates in China and predominance of sequence type 19 with serotype III

Antimicrob Agents Chemother. 2013 Mar;57(3):1538-41. doi: 10.1128/AAC.02317-12. Epub 2013 Jan 7.

Abstract

A total of 146 group B streptococcus isolates from 8 cities across China belonged to four serotypes. Serotype Ia was more common in children. A high prevalence of resistance was observed for levofloxacin (37.7%), erythromycin (71.2%), clindamycin, (53.4%), and tetracycline (81.5%). The levofloxacin and clindamycin resistances among the 4 serotypes differed significantly. Eighty percent of fluoroquinolone-resistant isolates belonged to the sequence type 19 (ST19)/serotype III clone, with GyrA-ParC-ParE triple substitutions. This clone carried the erm(B), mef(E), and tet(M) genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • China / epidemiology
  • Clindamycin / pharmacology
  • Clindamycin / therapeutic use*
  • DNA Gyrase / genetics
  • DNA Topoisomerase IV / genetics
  • Drug Resistance, Bacterial / drug effects
  • Erythromycin / pharmacology
  • Erythromycin / therapeutic use*
  • Genes, Bacterial*
  • Humans
  • Levofloxacin*
  • Middle Aged
  • Mutation
  • Ofloxacin / pharmacology
  • Ofloxacin / therapeutic use*
  • Prevalence
  • Serotyping
  • Streptococcal Infections / drug therapy*
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology
  • Streptococcus agalactiae / drug effects*
  • Streptococcus agalactiae / genetics
  • Streptococcus agalactiae / isolation & purification
  • Tetracycline / pharmacology
  • Tetracycline / therapeutic use*

Substances

  • Anti-Bacterial Agents
  • Clindamycin
  • Erythromycin
  • Levofloxacin
  • Ofloxacin
  • DNA Topoisomerase IV
  • DNA Gyrase
  • Tetracycline