Abstract
A new amphiphilic membrane marker based on a water-soluble dendritic polyglycerol perylene imido dialkylester has been designed, synthesized, and its optical properties characterized. In water it forms fluorescently quenched micellar self-aggregates, but when incorporated into a lipophilic environment, it monomerizes, and the highly fluorescent properties of the perylene core are recovered. These properties make it an ideal candidate for the imaging of artificial and cellular membranes as demonstrated by biophysical studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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CHO Cells
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Cell Membrane / ultrastructure*
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Cricetinae
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Dendrimers / analysis*
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Dendrimers / chemical synthesis
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Fluorescent Dyes / analysis*
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Fluorescent Dyes / chemical synthesis
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Imides / analysis
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Imides / chemical synthesis
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Membranes, Artificial
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Micelles
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Microscopy, Confocal
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Perylene / analysis*
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Perylene / chemical synthesis
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Surface-Active Agents / analysis*
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Surface-Active Agents / chemical synthesis
Substances
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Dendrimers
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Fluorescent Dyes
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Imides
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Membranes, Artificial
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Micelles
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Surface-Active Agents
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Perylene