Importance of detecting multidrug resistance proteins in acute leukemia prognosis and therapy

J Clin Lab Anal. 2013 Jan;27(1):62-71. doi: 10.1002/jcla.21563. Epub 2013 Jan 4.

Abstract

Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice of therapy. Literature showed that the detection of these proteins, mainly ABCB1, is important in the AL prognosis. However, there is controversy regarding the methodology used for their detection. In summary, the expression and activity profiles of ABCB1, ABCC1, and LRP, proteins capable of promoting the efflux of a variety of chemotherapeutic agents from the cell cytoplasm represent one of the greatest causes of failure in AL treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / analysis*
  • ATP Binding Cassette Transporter, Subfamily B / metabolism
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / analysis
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Acute Disease
  • Biomarkers, Tumor / analysis*
  • Biomarkers, Tumor / metabolism
  • Cell Line, Tumor
  • Humans
  • Leukemia / metabolism*
  • Leukemia / pathology
  • Models, Biological
  • Multidrug Resistance-Associated Proteins / analysis
  • Multidrug Resistance-Associated Proteins / metabolism
  • Prognosis
  • Vault Ribonucleoprotein Particles / analysis
  • Vault Ribonucleoprotein Particles / metabolism

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Biomarkers, Tumor
  • Multidrug Resistance-Associated Proteins
  • Vault Ribonucleoprotein Particles
  • major vault protein
  • multidrug resistance-associated protein 1