Abstract
Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity. Injecting Im-3 into crickets induced paralysis, but no toxicity was apparent in mice after an intracerebroventricular injection. Im-3 shares sequence similarity to scorpion β-toxins that specifically affect insect sodium channels.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Arthropod Venoms / chemistry*
-
Arthropod Venoms / classification
-
Arthropod Venoms / isolation & purification
-
Arthropod Venoms / pharmacology
-
Chromatography, High Pressure Liquid
-
Gryllidae / drug effects*
-
Gryllidae / physiology
-
Injections, Intraventricular
-
Male
-
Mice
-
Mice, Inbred ICR
-
Molecular Sequence Data
-
Neurotoxins / chemistry*
-
Neurotoxins / classification
-
Neurotoxins / isolation & purification
-
Neurotoxins / pharmacology
-
Phylogeny
-
Scorpions / chemistry*
-
Scorpions / pathogenicity
-
Sequence Alignment
-
Sequence Analysis, Protein
-
Sequence Homology, Amino Acid
-
Sodium Channel Blockers / chemistry*
-
Sodium Channel Blockers / classification
-
Sodium Channel Blockers / isolation & purification
-
Sodium Channel Blockers / pharmacology
-
Sodium Channels / metabolism
-
Species Specificity
Substances
-
Arthropod Venoms
-
Neurotoxins
-
Sodium Channel Blockers
-
Sodium Channels