A rapidly recurring cutaneous xanthogranuloma-like histiocytic tumor: a diagnostic challenge

Am J Dermatopathol. 2013 Jun;35(4):e60-2. doi: 10.1097/DAD.0b013e31827b763f.

Abstract

Xanthogranuloma (XG) is a benign cutaneous histiocytic tumor occurring mainly in young children. Onset in adulthood is rarely observed. We encountered an unusual case of an XG-like cutaneous tumor on the scalp of a 50-year-old man. The tumor recurred with multiple satellite nodules soon after surgical excision. This unusual clinical behavior has not previously been described for XG and caused a diagnostic challenge; it was unclear whether the tumor was an atypical XG or a malignant dermal tumor mimicking an XG. Our analyses favored an XG-like dermal histiocytic tumor. A longer follow-up and reports of similar cases will reveal its true nature.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biopsy
  • Granuloma / metabolism
  • Granuloma / pathology*
  • Granuloma / surgery
  • Histiocytic Disorders, Malignant / metabolism
  • Histiocytic Disorders, Malignant / pathology*
  • Histiocytic Disorders, Malignant / surgery
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local*
  • Reoperation
  • Scalp / chemistry
  • Scalp / pathology*
  • Scalp / surgery
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery
  • Treatment Outcome
  • Xanthomatosis / metabolism
  • Xanthomatosis / pathology*
  • Xanthomatosis / surgery

Substances

  • Biomarkers, Tumor