Targeting DNA damage response: threshold, chromatin landscape and beyond

Stefania Gonfloni

doi:10.1016/j.pharmthera.2012.12.006

Targeting DNA damage response: threshold, chromatin landscape and beyond

Pharmacol Ther. 2013 Apr;138(1):46-52. doi: 10.1016/j.pharmthera.2012.12.006. Epub 2013 Jan 4.

Author

Stefania Gonfloni¹

Affiliation

¹ Department of Biology, University of Rome Tor Vergata, via della Ricerca Scientifica, I-00133 Rome, Italy. Stefania.Gonfloni@uniroma2.it

PMID: 23291058
DOI: 10.1016/j.pharmthera.2012.12.006

Abstract

Cells are continually exposed to DNA assaults from exogenous and endogenous sources. To maintain genomic integrity, cells have evolved a highly conserved mechanism for repairing DNA lesions and, in particular, DNA double strand breaks (DSBs). Emerging evidence indicates that DNA repair/signaling machinery acts in an integrated fashion with chromatin structure at damaged sites. This review focuses on the interplay between histone modifications and the chromatin-mediated response to DNA damage.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chromatin / metabolism
DNA Damage*
DNA Repair*
Histones / metabolism

Substances

Chromatin
Histones