Retinal angiomatous proliferation occurring after radiotherapy

Abstract

Purpose: To describe two cases of retinal angiomatous proliferation (RAP)-like lesion following radiation therapy for primary tumor.

Patients and methods: Retrospective evaluation of two patients with previous irradiation treatment for a pleomorphic adenoma of the lacrimal gland and a vocal cord carcinoma, respectively. Visual acuity (VA), fluorescein angiography and optical coherence tomography were performed and demonstrated a RAP-like lesion in both cases. Treatment with intravitreal injections of Ranibizumab was performed with a follow-up of 19 and 10 months, respectively.

Results: Both the patients had a positive response to the treatment with improvement in VA and reduction of intraretinal fluid.

Conclusion: RAP-like lesions can develop following radiation treatment for a primary tumor. In patients presenting with idiopathic RAP, a history of prior radiotherapy should be considered.